Association of Helicobacter Pylori Infection and Gastric Cancer

Thakur S, Basnet RB, Sigdel D Basnet BK, Shrestha D, Poudel N,

Abstract


Introduction: Gastric cancer remains one of the most common cancers worldwide and the second leading cause of cancer mortality in the world. Helicobacter Pylori is a major risk factor. Early detection of infection and eradication therapy will probably reduce the incidence of stomach cancer. This study is carried out to see the association of the H. pylori infection in gastric cancer patients in our population.

Methods: This is a prospective cross sectional descriptive study done in Gastroenterology unit, Department of medicine, National Academy of Medical Sciences, Bir Hospital. Patients who were suspected of cancer of stomach clinically as well as endoscopically,their thorough history was taken and demographic profiles like age, sex and geographic location were recorded. Similarly, symptoms, risk factors and endoscopic finding were recorded. Likewise, result of rapid urease test and histopathology results were documented.

Results: Male patients were seen to be more frequently affected than females with stomach cancer which is 22 (59.46%) with male: female ratio being 1.47:1. The mean age of the subject was 61.14 years with SD of ±13.82 years and the highest number of patients were from 61 to 70 years age group amounting to 27.03 %. Cancer of antropyloric region was seen highest. Out of the 25 cases 16 (64%) were H. pylori positive with OR: 2.86, 95% C. I.: 0.24-34.67. Among the studied 37 patients with Histopathology confirmed adenocarcinoma of stomach, 21(56.75% with 95% C I: 39.48% - 72.90%) patients had H. pylori positive. H. pylori infection could be the etiological factor.

Conclusion: Males were seen to be affected more than female in case of stomach cancer and the incidence and relative risk of H. pylori infection was significantly higher in distal cancers of stomach.

Full Text:

View Pdf