INTRODUCTION: There is a paucity of data pertaining to spectrum of renal diseases in Nepal, partcular over a period of many years. The present study highlights specimen of symptomatc renal disorders at a tertary care hospital of Nepal over a period of eight years.  Materials and Methods : It included 8589 patents either presentng for the frst tme to nephrology outpatent department or admited between April1998 - March 2005 to the insttute. The data of eight years duraton were analysed retrospectvely and patents were grouped in diferent renal syndromes. RESULTS: Mean age of patents was (38.79 ± 15.15 years) with male preponderance in all renal syndromes. The number of patents atending  the OPD and getng admited increased progressively over the years. Total admissions in nephrology accounted for 5.6% of all medical inpatents in the year 1998 whereas the rato increased to 16 % in the year 2005. Total admissions increased overall but the proportonate increase in nephrology was much greater.  Chronic Kidney disease (CKD) was the commonest presentaton (56.02%). Chronic glomerulonephrits (CGN) (42.3%) and diabetc nephropathy (DN) (21.1%) were leading causes of CKD. Polycystc kidney diseases was responsible for about 4% of all chronic kidney disease. Nephrotc syndrome accounted for 22.36% whereas acute renal failure (ARF) was seen in 12.84%.The number of patents admited for ARF also increased over the years 18 in 1998 to 97 in 2005. Medical ARF accounted for 2/3rd of the cases of ARF and surgical etology was seen in 1/5th of causes whereas obstetric cause was responsible for 1/7th of the cases. Septcemia was the commonest cause for ARF(21%)  followed by acute gastroenterits(15.8%). Multple wasp and hornet bites accounted for nearly 8.2% of all ARF patents. The number of patents presentng as septcemia ARF also gradually increased over the years. Other presentatons were acute nephritc syndrome (6.75%) and asymptomatc urinary abnormality (AUA) (0.99%). Membrano Proliferatve Glomerulonephrits was the commonest primary GN among kidney biopsy specimens (44%).CONCLUSION: It is the frst large study of its kind from a tertary health care centre of  Nepal. Male patents in their peak of life (3rd and 4th decade) were the major candidates requiring renal care with CKD as the commonest presentaton and diabetc nephropathy as the second commonest cause of CKD afer CGN. We need more studies on spectrum of renal diseases for beter available resource management. Key words: Renal disorders, Chronic Kidney disease, Chronic glomerulonephrits, Diabetc Nephrology